Corneal Physician Bulletin: Anterior Segment Condition Linked With Increased Risk of Dementia

            Patients who have AMD, cataract or diabetes-related eye disease (DRED) are at a greater risk of dementia, and individuals who have both ophthalmic and systemic conditions are at a higher risk of dementia vs. those with an ophthalmic or systemic condition alone, reports the British Journal of Ophthalmology.1
            Specifically, of more than 1,263,513 person-years of follow up, 2,304 cases of incident dementia were recorded. In breaking it down by eye condition, the multivariable-adjusted HRs (95% CI) for dementia linked with AMD, cataract and DRED, and glaucoma at baseline were 1.26 (1.05 to 1.52), 1.11 (1.00 to 1.24), 1.61 (1.30 to 2.00) and (1.07 (0.92 to 1.25), respectively. Additionally, those who had a cataract and a systemic condition were 1.19 to 2.29 times more likely to develop dementia vs. those who did not have cataract and systemic conditions. Further, diabetes, hypertension, heart disease, depression, and stroke, discovered during follow-up, mediated the link between cataract and incident dementia, as well as the link between DRED and incident dementia.
            The study was comprised of 12,364 adults ages 55 to 73 from the UK Biobank cohort, who were evaluated between 2006 and 2010 at baseline and were followed up until the beginning of 2021. Incident dementia was determined employing hospital inpatient, death records and self-reported data.
1. Shang X, Zhu Z, Huang Y, et al. Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank. Br J Ophthalmol. 2021 Sep 13;bjophthalmol-2021-319508. doi: 10.1136/bjophthalmol-2021-319508.