Corneal Physician Bulletin: Mitomycin-C Prevents Corneal Haze Post PRK Procedure

            Mitomycin-C (MMC), used prophylactically, precludes corneal haze in myopic patients safely and effectively after transepithelial photorefractive keratectomy (T-PRK), reported a study in Clinical Ophthalmology. Additionally, MMC did not substantially affect corneal endothelial density or number.1
            Specifically, 119 out of 120 eyes that underwent TPK had “significant prevention of corneal haze,” and the eyes either showed no significant changes or non-significant changes in corneal endothelial density and numbers.
            The study was comprised of 120 eyes of 60 patients who had low, moderate, and high myopia and underwent T-PRK. These patients were placed into three different groups, according to ablation depth: Group A had low myopia sans MMC; Group B had low myopia with MMC; and Group C had moderate/high myopia with MMC. All formulations were 0.02%. Using specular microscopy preoperatively and postoperatively, the researchers documented cell density, number of cells, coefficient of variation, central corneal thickness, hexagonality, average cell area (AVG), and its standard deviation (SD) 
1. Al-Mohaimeed MM. Effect of Prophylactic Mitomycin C on Corneal Endothelium Following Transepithelial Photorefractive Keratectomy in Myopic Patients. Clin Ophthalmol. 2022;16:2813-2822. doi: 10.2147/OPTH.S375587. eCollection 2022.